The former head of the vaccines taskforce has said the current COVID jabs are 'not good enough'.
"What's gone wrong is there's been no expert or leader that's put in place to coordinate the activities," she said.
"Everything from vaccine innovation and scale up to landscaping - figuring out where the new variants may come from, the new potential pandemic viruses - people that understand manufacturing, scaling up clinical development, regulation."All of those have gone. Maybe there is somebody secret out there that's doing that, but not as far as I can see.
"To begin with I thought it was a lack of experience of officials since we don't have a lot of people within Whitehall that understand vaccines, relationships with industry, all of that," she said. "But actually, I'm beginning to think this is deliberate government policy - just not to invest and just not to support the sector.
"I cannot explain why we haven't appointed somebody who can actually bring all this together because we've got the capabilities and yet, systematically, things are being dismantled that we put in place."
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Alterations of the fecal microbiota in relation to acute COVID-19 infection and recovery - Molecular BiomedicinePeople with acute COVID-19 due to SARS-CoV-2 infection experience a range of symptoms, but major factors contributing to severe clinical outcomes remain to be understood. Emerging evidence suggests associations between the gut microbiome and the severity and progression of COVID-19. To better understand the host-microbiota interactions in acute COVID-19, we characterized the intestinal microbiome of patients with active SARS-CoV-2 infection in comparison to recovered patients and uninfected healthy controls. We performed 16S rRNA sequencing of stool samples collected between May 2020 and January 2021 from 20 COVID-19-positive patients, 20 COVID-19-recovered subjects and 20 healthy controls. COVID-19-positive patients had altered microbiome community characteristics compared to the recovered and control subjects, as assessed by both α- and β-diversity differences. In COVID-19-positive patients, we observed depletion of Bacteroidaceae, Ruminococcaceae, and Lachnospiraceae, as well as decreased relative abundances of the genera Faecalibacterium, Adlercreutzia, and the Eubacterium brachy group. The enrichment of Prevotellaceae with COVID-19 infection continued after viral clearance; antibiotic use induced further gut microbiota perturbations in COVID-19-positive patients. In conclusion, we present evidence that acute COVID-19 induces gut microbiota dysbiosis with depletion of particular populations of commensal bacteria, a phenomenon heightened by antibiotic exposure, but the general effects do not persist post-recovery.
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