⚡ Our February issue is live! With research, news and opinions covering COVID19 vaccine hesitancy, CRISPR gene editing, precision diabetes, NASH, cancer clinical trials and much more. Check it out here:
Tumor mutation burden is an imperfect predictor of response to immunotherapies. Mutations in regions of the genome unlikely to undergo loss during tumor evolution constitute a persistent tumor mutation burden that may drive sustained immunological tumor control in the context of cancer immunotherapy.
Smoldering multiple myeloma is an asymptomatic precursor condition to multiple myeloma, a cancer in the bone marrow. We conducted a population-based screening study — in which 51% of the population over 40 years of age in Iceland participated — and found that the prevalence of smoldering multiple myeloma was 0.5% in the study population.
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Protecting public health in Iran in the face of oppressionProtecting public health in Iran in the face of oppression. Correspondence from PardisSabeti and colleagues harvard HarvardChanSPH broadinstitute
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Genomic medicine offers diagnostic hope for people with rare diseases | Pediatric ResearchAn 18-year-old experienced symptoms of her rare disease from birth, but it wasn’t until 2020 that she got her diagnosis thanks to genomic medicine.
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‘Sleep as medicine,’ or how to make a hospital stay less unhealthySome experts say sleep deprivation is a contributor to “post-hospital syndrome” — a term for the weakened immune systems, loss of body mass and other impairments that land many people back in a hospital soon after discharge.
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Structure and thiazide inhibition mechanism of the human Na–Cl cotransporter - NatureUsing cryo-electron microscopy, the structures of human Na–Cl cotransporter are determined alone and in complex with a thiazide diuretic.
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A universal interface for plug-and-play assembly of stretchable devices - NatureA universal interface connects soft, rigid and encapsulation modules together to form robust, stretchable devices in a plug-and-play manner by pressing without using pastes, which will simplify and accelerate development of on-skin and implantable devices.
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A NPAS4–NuA4 complex couples synaptic activity to DNA repair - NatureA neuron-specific activity-dependent DNA repair mechanism is identified, the impairment of which may lead to neurodevelopmental disorders, neurodegeneration and ageing.
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