Is it possible that a single biomarker can detect all types of diseases related to dopamine deficiency in the brain? Yes, that's what a research group is discovering. 'We have observed that an enzyme in cerebrospinal fluid and in blood is a useful marker for identifying all types of Parkinson's-related diseases with high accuracy,' says the study leader.
Is it possible that a single biomarker can detect all types of diseases related to dopamine deficiency in the brain? Yes, that's what a research group in Lund is discovering."We have observed that an enzyme in cerebrospinal fluid and in blood is a useful marker for identifying all types of Parkinson's-related diseases with high accuracy," says Oskar Hansson, who led the study.The marker in question is called DOPA decarboxylase .
"We have used advanced techniques that allow us to measure thousands of proteins simultaneously in a small amount of sample. We conducted this in 428 individuals to identify biomarkers that can indicate whether a patient with motor disturbances or cognitive difficulties has damage to the dopamine system in the brain. We found that if a patient has a disorder in the dopamine system, the levels of the biomarker DDC increase, regardless of where they are in the course of the disease.
The researchers' findings were verified in an additional group of 152 individuals. Furthermore, they demonstrated that the new biomarker is also significantly increased in blood by analyzing blood plasma samples from 174 individuals. Damage to the dopamine system in the brain can also be detected through PET camera examinations. However, this is a very costly and complicated method that is only available at specialized memory clinics.
"Since the symptoms of various neurodegenerative brain diseases resemble each other, there is a significant risk of misdiagnosis and thus improper treatment. Therefore, it is crucial to find safer diagnostic tools and methods, and we are focusing on that in our research.
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