Treatment with a novel, minimally invasive brain pacemaker cut seizure frequency by at least 50% in patients with drug-resistant focal epilepsy, new research shows.
For the study, investigators analyzed pooled data from the EASEE II and PIMIDES I clinical trials, first-in-human trials of the system that were conducted at seven European epilepsy centers. The nonrandomized, open-label studies began in January 2019 and January 2020, respectively, and ended in July 2021.
In total, 32 individuals underwent treatment at least until the 8-month post-implant follow-up visit. There were no serious adverse events reported, which Schulze-Bonhage said is"different from devices implanted intracranially, in whichAdditional studies are under way to determine whether the efficacy reported in this study was driven more by HFS or DLS stimulation, information that would help fine-tune the device. Investigators also want to identify factors that contributed to some patients' higher response rates compared with others.
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