European researchers announced Saturday that a new treatment for advanced melanoma was more effective than the leading existing therapy in a Phase 3 clinical trial.
And while it’s been explored for solid tumors, which make up the majority of cancers, including melanoma, these tumors present challenges that blood cancers do not. Many blood cancers are homogeneous, meaning their cells are uniform. This gives CAR-T therapy a clear target to latch onto and attack. But solid tumors tend to have a number of different cell types that vary largely between cancer types, said Dr.
Those cells are then infused back into the patient’s bloodstream, where they can work to kill the cancer. In the trial, 168 patients with metastatic melanoma were randomly assigned to receive either TIL treatment or the current standard treatment, ancalled ipilimumab. Ipilimumab is typically used in people who don’t respond to a first-line treatment called anti-PD-1 therapy; nearly all of the patients in the trial had not responded to that treatment.
“It’s the first time that we’ve had a result like that with a cell therapy immunotherapy for patients with melanoma,” said Davies, who is on the scientific advisory board for Iovance Biotherapeutics, a California-based company that is conducting aMelanoma rates have been rising rapidly in the United States over the past 30 years, and although metastatic melanoma, the most serious stage of the disease, in which the cancer has spread to other parts of the body, is relatively rare, it’s often...
“This approach can work in many cancer types, but for tumors other than melanoma it is essential to select the right TIL to use. Melanoma is unique because you can use all TIL without selection,” said Rosenberg, who was the first person to propose TIL therapy in the 1980s.
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