Scientists have reported the outcomes of the first multi-center randomized trial comparing the effects of two diets. A clinical trial funded by the National Institutes of Health has found that eliminating just animal milk from the diet of adults with eosinophilic esophagitis (EoE) is as effective i
Eosinophils are a type of white blood cell that play a role in the body’s immune response. They are often involved in the immune response to allergens and parasites, and their presence in increased numbers can be an indicator of various allergic and inflammatory conditions. Eosinophils are commonly associated with conditions such as asthma, atopic dermatitis, and eosinophilic esophagitis.
Excluding certain foods from the diet has been a cornerstone of EoE treatment. During the early 2000s, researchers found that eliminating six common food triggers of esophageal injury—milk, egg, wheat, soy, fish, and nuts—substantially reduced signs and symptoms of EoE. This six-food elimination diet became a common approach to managing the disease.
The trial involved 129 adults ages 18 to 60 years with a confirmed EoE diagnosis, active EoE symptoms, and a high number of eosinophils in esophageal tissue. Volunteers enrolled in the trial at one of 10 U.S. medical centers that participate in the, part of the NIH-funded Rare Diseases Clinical Research Network. Participants were assigned at random to either the 1FED, which eliminated only animal milk from the diet, or the 6FED.
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