Speeding up the search for effective new COVID-19 antivirals. An arsenal of measures to prevent and treat viral infections is needed for the world to put the COVID-19 pandemic in the rearview mirror and prevent other coronaviruses from causing havoc. To develop effective new medications for this pu
Scientists are making progress on the development of pan-coronavirus antiviral medications that can treat people infected by SARS-CoV-2 and other coronaviruses.An arsenal of measures to prevent and treat viral infections is needed for the world to put thepandemic in the rearview mirror and prevent other coronaviruses from causing havoc. To develop effective new medications for this purpose, scientists are working to target one protein, nsp13, that these viruses need to replicate.
, one research team describes a new approach to identifying molecules that interfere with this protein, a step toward the development of pan-coronavirus antivirals.prepare the immune system to fight off the virus, antiviral medications treat infections that have already started by interfering with an essential part of the viral machinery.
Because nsp13’s energy-releasing activity increases in the presence of single-stranded nucleic acids, the team devised tests that focus on this activity in the presence and absence of single-stranded. In both cases, the tests glow more brightly when less ATP is broken down, which occurs when something is interfering with nsp13. They used one of these tests to screen a library of 5,000 small molecules, turning up 17 promising results.
Additional work, including performing the second test, narrowed the field to only six compounds — potential starting points for the development of future, more-potent nsp13 inhibitors, according to the researchers. The new tests, meanwhile, could be used to efficiently screen large numbers of small molecules for activity against nsp13, or to confirm results from other approaches, they say.
Reference: “Kinetic Characterization of SARS-CoV-2 nsp13 ATPase Activity and Discovery of Small-Molecule Inhibitors” 13 July 2022,The authors acknowledge funding from the University of Toronto and support of the Structural Genomics Consortium, University of Toronto site.
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