Critical Path Institute (C-Path) is thrilled to announce its Polycystic Kidney Disease Outcomes Consortium (PKDOC) has been awarded an Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD) focused Broad Agency Announcement (BAA) contract from the U.S. Food and Drug Administration (FDA).
Critical Path Institute Sep 24 2024 Critical Path Institute is thrilled to announce its Polycystic Kidney Disease Outcomes Consortium has been awarded an Autosomal Dominant Tubulointerstitial Kidney Disease focused Broad Agency Announcement contract from the U.S. Food and Drug Administration .
ADTKD only affects the kidney, resulting in slowly worsening kidney function and the need for dialysis or kidney transplant at an average age of 45 years. It is caused predominantly by genetic changes in the UMOD and MUC1 genes. Because of the inheritance pattern , a child of an affected parent has a 50% chance of also being affected. Thus, many family members have kidney disease and will eventually need a kidney transplant or dialysis.
Given its recent identification as a cause of kidney disease and its rarity, little is known about factors that affect progression of kidney disease in ADTKD. Understanding rates of progression is important for patients and important for the development of future clinical trials. C-Path will now play a major role in analyzing available clinical data about ADTKD and helping to better understand the factors associated with disease progression.
We are very grateful for the support we have received from FDA to pursue this important project. This proposal represents our commitment to advancing the quantitative understanding of ADTKD progression through incorporation of relevant biomarkers into disease progression models, thus allowing a path forward for more efficient clinical trials and eventual drug approvals for this devastating disease.
Kidney Dialysis Food Genes Genetic Kidney Disease Kidney Transplant Laboratory Ph Polycystic Kidney Disease Transplant
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