A new study, recently published in Nature Communications, unveils a powerful new method for studying the inner workings of cell nuclei during embryonic stem cell differentiation.
Within the nucleus of an embryonic stem cell , HP1α bodies can be observed. These bodies exhibit phase separation, forming distinct liquid sub-domains with varying densities, as represented by the light blue and blue regions, respectively. Analogously, this phase separation can be likened to a drop of oil suspended in water or to dense crowds in a public space . The borders between denser and less dense areas are highlighted in green and red.
These protein-based reporters helped them understand how parts of DNA called heterochromatin are packed inside the cell nucleus and what happens to these parts during cell development. This discovery gives us important information about how our cells work and change over time.
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