New insights into the role of T-cells during long COVID Coronavirus Disease COVID TCell biorxivpreprint UCSF uni_ulm
By Neha MathurFeb 14 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study posted to the bioRxiv* preprint server, researchers use three “omics” and serological assays to characterize the trajectory of long COVID in patients eight months after recovering from the severe acute respiratory syndrome coronavirus 2 infection but before receiving any coronavirus disease 2019 vaccine.
Serological analyses have also identified elevated levels of SARS-CoV-2 autoantibodies in LC patients; however, these observations have not been consistently reported. In addition, single-cell transcriptomics of peripheral blood mononuclear cells have identified increased levels of specific LC phenotypes, including myeloid and natural killer subsets.
For both LC and non-LC individuals, the researchers comprehensively monitored the expression IFNγ, IL-2, macrophage inflammatory protein 1b , tumor necrosis factor-alpha , and IL-6. LC patients in the current study did not harbor more polyfunctional anti-SARS-CoV-2 T-cells in the CD4 and CD8 compartments.
One subset of cytotoxic and stimulated T-cells was amplified to a greater extent in females with LC, while males showed a contrasting pattern. A correlation between cytotoxic T-cells and gastrointestinal LC symptoms was also observed. Taken together, these findings indicate that future studies are needed to establish whether LC-related cytotoxic T-cell function varies with gender and GI symptoms.
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