Research from last year shows a transplant of gut microbes—in the form of feces—from young mice to old ones can reverse signs of brain aging. ScienceMagArchives
Nature Aging“It’s almost like … we could press the rewind button on the aging process,” says John Cryan, a neuroscientist at University College Cork who led the new study.
However, some things did not noticeably change for older mice given young feces. Many types of gut bacteria remained the same, for example, and the old mice didn’t become more social, which Cryan found surprising, because he’s seen the microbiome impact social interactions in other studies. Arya Biragyn, a molecular biologist at the National Institute on Aging, says he would have liked the team to have done more to show the microbiomes had actually changed in the older mice. Because the researchers checked for differences in the gut microbiome soon after the transplants, there’s no way to know whether the new microbes had truly moved in or were just passing through, he argues.
Gibbons also notes that the field of fecal transplants in mice remains a mixed bag. Whereas some studies have found such proceduresCryan himself cautions about jumping the gun to humans, given that the study was entirely based on rodents. Still, he argues, the work offers hope. “The good thing about your microbiome—as opposed to your genome—is that you can change it.”
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