New research examines how COVID-19 affects immune-compromised people COVID19 Pandemic Cancer Steroids Vaccination Immunization Medical HIV Respiratory Infections PLOSMedicine LivUni EdinburghUni UniLeidenNews UofGlasgow imperialcollege
By Tarun Sai LomteFeb 5 2023Reviewed by Benedette Cuffari, M.Sc. A recent study published in the journal PLoS Medicine evaluates outcomes in immunocompromised patients hospitalized with the coronavirus disease 2019 .
About the study In the present study, adults hospitalized with COVID-19 between January 17, 2020, and February 28, 2022, were enrolled in a prospective observational cohort study known as the International Severe Acute Respiratory and Emerging Infection Consortium Clinical Characterization Protocol in the United Kingdom.
Multivariable logistic regression was performed to assess in-hospital mortality with adjustments for sex, age, ethnicity, comorbidities, vaccination, and deprivation index. Secondary outcome measures were similarly adjusted for the specified variables. Cancer Research eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy About 95% of immunocompromised patients were comorbid. Chronic pulmonary disease, malignant neoplasm, and hematologic and rheumatologic diseases were more common in immunocompromised patients, while diabetes, chronic cardiac disease, obesity, and hypertension were similar between the two groups.
Overall, 29% of immunocompromised and 21% of immunocompetent patients died. The highest mortality rate was observed in cancer patients and pre-hospitalization steroid users.
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