Brazilian scientists carried out preclinical trials on mice to determine the optimal dose and method of administration. The findings indicate that high daily doses of the probiotic are required to obtain its benefits. According to a recent study conducted in Brazil, a daily serving of the yeast str
CFU/mL. The researchers also investigated the effects of administering 100 μL of the solution with 10Male laboratory mice were intraperitoneally sensitized and nasally challenged with ovalbumin to induce allergic airway inflammation. They were fed the yeast via a tube leading down the throat to the stomach .
The researchers, who are affiliated with FMRP-USP and UFMG’s Institute of Biological Sciences, discovered that both daily administration of the probiotic and administration on alternate days significantly reduced bronchial hypersensitivity in comparison with the control group, which was given only saline solution. Bronchial hypersensitivity is excessive constriction of the airways in response to a stimulus and is one of the main characteristics of asthma.
However, only daily administration of the highest dose reduced airway inflammation in the asthmatic mice. “We measured the degree of inflammation in terms of eosinophil count and interferon levels,” Borges said. Eosinophils are immune system cells, and interferons also help the body fight infection. Both are markers of asthmatic inflammation. “They were both considerably reduced in the mice treated with the probiotic.
Airway and lung inflammation was not significantly reduced by administration of the probiotic either daily or on alternate days at concentrations of 10UFC/mL. “From the public policy standpoint, having a natural product like a probiotic, which has practically no side-effects, with the potential to prevent a health problem as widespread as asthma is very important,” Borges said.
Bread containing the yeast has been developed and found to have a similar preventive effect in master’s research supervised by Borges in partnership with colleagues at UFMG and the State University of Campinas . The product has been patented and will soon be reported on in scientific journals.UFMG A-905 on the Prevention of Asthma in an Animal Model” by Thamires M. S. Milani, Camila M. Sandy, Ana Paula Carvalho Thiers Calazans, Rosana Q. Silva, Vanessa M. B. Fonseca, Flaviano S.
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