A large NIH study of autism risk factors finds that 3 to 5 percent of children with an aunt or uncle on the autism spectrum also have ASD — at least twice the rate found in the general population.
A child whose aunt or uncle has autism spectrum disorder is significantly more likely to have autism, according to a large study of more than 850,000 families in Sweden. The study, funded by that National Institutes of Health , is the first population-wide estimate of autism risk in children.
In studying the Swedish national registers of births and family relationships for children born between 2003 and 2012, researchers found thatwas diagnosed in approximately 13,000 children, or 1.5 percent of the total. Among the population of children with an autistic aunt or uncle, this number jumped to 3 to 5 percent. This suggests that having an aunt or uncle with autism may increase a child’s likelihood of having ASD by 100 to 230%.
The research showed this autism link for children with both maternal and paternal relatives on the spectrum. Children of mothers with one or more siblings with ASD were roughly three times more likely to have the disorder than were children in the general population. Children of fathers with one or more siblings with ASD were twice as likely to have ASD as were children in the general population.
This finding debunks the theory that biological mothers are less likely to pass along genes associated with autism than are fathers. Researchers say their study results indicate that being female does not offer more tolerance of autism risk factors.
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