Researchers examine the expected survival of people at each stage of Alzheimer's disease.
By Dr. Liji Thomas, MDAug 17 2023Reviewed by Benedette Cuffari, M.Sc. Alzheimer’s disease is the leading cause of dementia illness in the elderly and causes a significant loss of independence, productivity, and health. A new study recently published in BMC Neurology examines the expected survival of people at each stage of AD, as well as the estimated increase in the mortality risk at each stage from baseline mortality in people without cognitive impairment.
The aging population increases the likelihood of rising AD cases, thus causing clinicians and drug development researchers to prioritize the prevention and treatment of AD. This requires a clear understanding of mortality risk at each stage of AD, both for patient and caretaker education, as well as allow researchers to evaluate the efficacy of any proposed therapy.
The current study had a retrospective design and comprised over 12,000 people in the United States with mild to severe cognitive impairment due to AD and were over 50 years of age. Over a follow-up period of up to 15 years, researchers examined the overall survival and hazard ratios for death from all causes in these patients as compared to those with normal cognition. All data was obtained from the Uniform Data Set of the National Alzheimer’s Coordinating Center .
People with AD who developed MCI or with dementia due to AD lived for a median of three to 12 years. Most AD patients with severe dementia died before the end of the study period. However, there was no overall increase in the risk of death in the AD-MCI group as compared to those with normal cognition when adjusted for other factors that could impact the mortality risk as well as compensate for the progression of the disease over time.
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