New study on mice links a commonly-consumed sweetener to an increase in anxiety for generations

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New study on mice links a commonly-consumed sweetener to an increase in anxiety for generations
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It's a commonly used sweetener that can be found in soft beverages, frozen desserts, yogurt, etc.

in the exposed animals but it also influenced up to two offspring of males that were exposed to the sweetener.“What this study is showing is we need to look back at the environmental factors, because what we see today is not only what’s happening today, but what happened two generations ago and maybe even longer,” said co-author Pradeep Bhide, the Jim and Betty Ann Rodgers Eminent Scholar Chair of Developmental Neuroscience in the Department of Biomedical Sciences.

As per the press release, aspartame breaks down into aspartic acid, phenylalanine, and methanol in the body, all of which can have potent impacts on the central nervous system. In their clinical trials, researchers fed mice water with aspartame at a dosage that was around 15 percent of the FDA's recommended maximum daily amount for humans. For mice, this dosage is equivalent to consuming six to eight eight-ounce cans of diet soda a day for humans.

Continued for 12 weeks at this dosage, researchers observed more anxiety-like behavior in the exposed mice and the offspring of males for up to two generations.“It was such a robust anxiety-like trait that I don’t think any of us were anticipating we would see,” Jones said. “It was completely unexpected. Usually, you see subtle changes.

The next step for researchers is to publish another article from this study that focuses on how aspartame affects memory. Future studies will pinpoint the molecular processes that affect how aspartame's effects are passed down through the generations.

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