New study reveals mast cells' surprising role in allergy-related avoidance behavior Nature mastcells allergies allergy behavior behviour
By Neha MathurJul 14 2023Reviewed by Lily Ramsey, LLM In a recent study published in Nature, researchers used a mouse model to show that mast cells and immunoglobulin E are the key orchestrators of antigen-specific avoidance, a behavioral adaptation to acute allergic reactions. A topic that remains poorly understood in the framework of type 2 immunity.
Mast cells express high-affinity IgE receptors that bind antigen-specific IgE upon reexposure to the same antigen. Mast cells release proteases, serotonin, histamines, and leukotrienes , which signal avoidance behavior likely causing an allergic reaction. On day 20, they subjected mice to a drink avoidance test, a behavioral assay adapted from Cara et al., which ascertained their preference for egg white water over plain water. The team continuously recorded the drinking preferences of each test animal.
Results The researchers noted that while non-immunized mice preferred egg white water over plain water, OVA-immunized mice avoided egg white water in a mast cell-dependent manner. Another notable observation was that immune gene induction was lower in mast-cell-deficient mice, suggesting immune activation might not be completely mast-cell dependent.
Deutschland Neuesten Nachrichten, Deutschland Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
Nicole Kidman's daughter Bella Cruise's very glamorous new look revealed in stunning new photoThe Big Little Lies actress is married to country music star Keith Urban
Weiterlesen »
Avian flu cases confirmed on Scottish nature reservesA task force is on 'high alert' after an increase in reports of dead seabirds on Scotland's coasts.
Weiterlesen »
Food, Nature and Nudes: Two Sisters Collaborate on an Erotic Photo BookFood, nudes and nature 🍅 Created by sisters, artist duo Anna and Maria Ritsch, the new book Together Apart is a meditation on girlhood, sisterly bonds and life’s transitions: Photography by the Ritsch sisters
Weiterlesen »
Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients - Nature CommunicationsHere, Caballero et al. provide an in depth characterisation of patients colonized with single or mixed strains of Pseudomonas aeruginosa to demonstrate the impact of within-host diversity on the development of antibiotic resistance.
Weiterlesen »
Local translation in microglial processes is required for efficient phagocytosis - Nature NeuroscienceVasek et al. demonstrate that distal processes of microglia locally translate specific mRNAs including those related to immunity and phagocytosis. They then show that local protein synthesis is necessary for microglial process-initiated phagocytosis.
Weiterlesen »
33 wolf cut hair ideas for 2023, whether you're grunge, glam or edgyThe good news? It can be as edgy as you like.
Weiterlesen »