A new study showed that hydroxychloroquine doesn’t prevent the Covid-19 coronavirus infection ForbesFrontlines
Rather than examining if HCQ improved the clinical outcome of people infected with SARS-CoV-2, these researchers examined the use of HCQ as post-exposure prophylaxis . In other words, they wanted to understand if HCQ, when given shortly after exposure to the virus, could reduce the likelihood of infection. There is precedent for this approach. Numerous studies have shown that PEP can reduce the risk of HIV infection.
If the rate of infection in people exposed to the virus can be reduced, the number of new cases will drop, but this study does not provide evidence that hydroxychloroquine can fulfill this goal. To explore the ability of HCQ to prevent SARS-CoV-2 infections, the authors of this study enrolled over 800 people who had a moderate- or high-risk exposure to the virus. These individuals were randomly divided into two groups. Within four days of exposure, members of one group received HCQ, whereas members of the other group received a placebo. All individuals then were monitored. The conclusion: there was no discernible difference in the rate of infection in either group.
However, the study does have some limitations. Most notably, infections were defined primarily by the appearance of disease signs and symptoms. Because of the limited availability of PCR-based tests, the detection of asymptomatic infections was not possible. This means that it’s possible the post-exposure administration of HCQ reduced the number of these subclinical events.
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