New study using novel approach for glioblastoma treatment shows promising results, extending survival NatureMedicine
Immune checkpoint inhibitors are effective treatments for a variety of cancers, but they have had limited success in treating recurrent glioblastoma. This novel therapy involves the combination of an oncolytic virus and immune checkpoint inhibition, using an anti-PD-1 antibody as a targeted immunotherapy.
"Oncolytic viruses can overcome this limitation by creating a more favorable tumor microenvironment, which then helps to boost anti-tumor immune responses." UHN, which is the largest research and teaching hospital in Canada and the only Canadian institution involved in the study, treated the majority of the patients enrolled in the trial., show that this combination therapy is safe, well tolerated and prolongs patient survival. The therapy had no major unexpected adverse effects and yielded a median survival of 12.5 months—considerably longer than the six to eight months typically seen with existing therapies.
"We believe the key to our success was delivering the virus directly into the tumor prior to using systemic immunotherapy. Our results clearly signal that this can be a safe and effective approach," adds Dr. Nassiri.
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