Antibiotic resistant bacteria are experts in evolving new strategies to avoid being killed by antibiotics.
University of Southern DenmarkJul 1 2024
Thick and slimy biofilm The team discovered a mechanism, that reduces the formation of biofilm on the surface of P. Aeruginosa. The formation of sticky, slimy biofilm is a powerful tool used by bacteria to protect themselves against antibiotics – a trick also used by P. Aeruginosa. Bacteria strains can evolve individually and mutate quickly and constantly when they are under pressure. It is not uncommon for patients infected with a P. Aeruginosa strain to initially respond well to antibiotic treatment but then become resistant as the strain evolves resistance during treatment. Strains mutate, but their common core genome does not change.
"Currently, cell wall-targeted drugs are not widely used against P. Aeruginosa, but perhaps, they could start to be used as additives to help reduce biofilm production and improve access of the existing antibiotics to the cells."
Antibiotic Biochemistry Cell Cell Wall Genes Genome Microbiology Molecular Biology Nursing Research Stress
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