To be cost-effective compared with metformin for initial therapy for T2D, prices for an SGLT2 inhibitor or a GLP-1 agonist would have to fall by at least 70% and at least 90%, respectively, according to estimates. MedTwitter
However, to be cost-effective at under $150,000 per quality-adjusted life-years , SGLT2 inhibitors would need to cost less than $5 a day and GLP-1 agonists would have to cost less than $6 a day , a lot less than now.
One way that the newer drugs might be more widely affordable is if the government became involved, possibly by passing a law similar to the The researchers created a population simulation model based on the United Kingdom Prospective Diabetes Study, Outcomes Model version 2 for diabetes-related complications and mortality, with added information about hypoglycemic events, quality of life, and US costs.
The model projected that patients would have an improved life expectancy of 3.0 and 3.4 months from first-line SGLT2 inhibitors and GLP-1 agonists, respectively, compared to initial therapy with metformin due to reduced rates of macrovascular disease.
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