ISC23 Butylphthalide may improve outcomes after an acute ischemic stroke when given in addition to thrombolysis or endovascular treatment, a new report suggests.
when given in addition to thrombolysis or endovascular treatment, a new report suggests.
"Patients who received butylphthalide had less severe neurological symptoms and a better living status at 90 days post stroke compared to those who received the placebo," said co-author Baixue Jia, MD, an attending physician inat the Beijing Tiantan Hospital of Capital Medical University and a faculty member at the China National Clinical Research Center for Neurological Diseases in Beijing.
Along with an initial revascularization intervention chosen by their physician, participants were randomly selected to receive either butylphthalide or a placebo daily for 90 days. The drug was administered through daily intravenous injections for the first 14 days, after which patients received oral capsules for 76 days.
an initially serious to severe stroke and no remaining symptoms or a slight disability that impairs some activities but allows one to conduct daily living without assistance .Among the 1216 participants, 607 were assigned to the treatment group, and 609 were assigned to the placebo group. The average age was 66 years, and 68% were men.
Secondary events, such as recurrent stroke and intracranial hemorrhage, weren't significantly different between the butylphthalide and placebo groups.Jia and colleagues noted the need to understand how butylphthalide works in the brain. Animal studies have suggested several possible mechanisms, but it remains unclear.
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