Radiotheranostics embodies the convergence of diagnostic and therapeutic radiopharmaceuticals into a unified platform. In cancer treatment, radiotheranostic procedures typically involve the use of antibodies that bind to proteins abundantly found on the surface of cancerous cells. The antibodies are labeled with a suitable radioisotope, which facilitates imaging procedures used to diagnose cancer and can be used to target cancerous cells and bombard them with deadly radiation as a form of treatment.
Although radiolabeled antibodies show promise as a treatment for cancer, several hurdles impede their clinical translation. The most notable impediment is slow blood clearance, which causes bone marrow toxicities. Meanwhile, radiolabeled antibody fragments show rapid blood clearance, but cause accumulation and slow clearance of the radiolabeled particles from the kidneys, also known as renal retention.
Recently, medicinal chemistry researchers from Japan's Chiba University developed new radiolabeled antibody fragments and tested them in a murine model. They found that the novel radioisotope-labeled antibody fragments facilitate the rapid elimination of the resulting radiometabolites from murine kidneys. More specifically, the team developed 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid -based reagents for radiotheranostic applications.
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