Novel predictors of severe respiratory syncytial virus infections among infants below the age of one helsinkiuni medrxivpreprint ChildHealth Infants RSV
By Dr. Chinta SidharthanMar 3 2023Reviewed by Aimee Molineux *Important notice: medRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.
Hitherto, palivizumab was the only available monoclonal antibody immunoprophylactic, and due to the high cost and difficult administration process, it was only prescribed in high-risk cases. Recently the European Medicines Agency has approved a single injection monoclonal antibody treatment Nirsevimab to treat RSV infections. Additionally, maternal RSV vaccines that act through the placental transfer of antibodies have shown some success.
A total of 1510 candidate predictors were identified, comprising 487, 434, and 314 predictors related to the mother, father, and siblings, respectively, 166 predictors related to the pregnancy, 92 related to the infant’s health, and three composite variables such as a family history of asthma.
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