By creating a drug that’s based on part of the SARS-CoV-2 spike protein, researchers can block the virus from entering cells. The virus that causes COVID-19, called SARS-CoV-2, uses its spike protein in order to stick to and infect our cells. The final step for the virus to enter our cells is for
, and the University of Finland have generated a molecule based on the twisted part of the spike protein , which sticks itself onto the virus and prevents the spike protein from twisting. Their research shows that it prevents cells from infection even with new SARS-COV-2 variants. Yang’s work was published in thein October and was presented on Tuesday, February 21 at the 67th Annual Biophysical Society Meeting in San Diego, California.
The reason the longHR2_42 inhibitor may work against an evolving virus is that it is based on part of the spike protein that hasn’t changed even as other parts have. “In the virus, there are two parts of the spike protein that come together forming this bundle. So we simply took a short piece of one part of this bundle, and by synthesizing that small piece chemically, it can insert itself into the spike protein and prevent the virus from infecting cells,” Brunger explained.
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