Some people who live in a small Colombian community seem to have partial resistance to Alzheimer's. Researchers have identified people with genes that promote and prevent the early onset of the condition - in a discovery that could inspire new treatments
at University Medical Center Hamburg-Eppendorf in Germany and his colleagues have found a second similar case: a Colombian man who carries both the harmful mutation. This also gave him partial protection, as he similarly developed Alzheimer’s in his 70s.
, but their levels of tau were lower than is usually seen in Alzheimer’s – hinting that high tau is chiefly responsible for the symptoms of memory loss and confusion. The man also had a sister with both the harmful mutation and one copy of the newly discovered protective variant. She seems to have been slightly protected, as she had severeIn separate research, the team found that a few people in the Colombian community have a single copy of the Christchurch protective mutation, as well as the risky Alzheimer’s variant, and they also seem to have a moderate delay of dementia onset, says Sepulveda-Falla.
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