Phenotyping identifies long COVID subtypes LongCOVID InflammationMarkers DistinctProfiles COVID ImmuneActivation BloodProteome LongCOVID ProlongedSymptoms Research medrxivpreprint
By Dr. Priyom Bose, Ph.D.Jun 14 2023Reviewed by Benedette Cuffari, M.Sc. The ongoing coronavirus disease 2019 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 , has had a significant impact on the global economy and healthcare sector.
Although some studies have revealed the manifestation of persistent inflammation in adults with long COVID, these findings have been limited by the timing of samples, breadth of the considered immune mediators, and sample size. These limitations have led to an inconsistent association with symptoms. Related StoriesBased on clinical data, the patients were placed into six categories, of which included ‘Recovered,’ ‘Fatigue,’ ‘Cardiorespiratory,’ ‘GI,’ ‘Cognitive impairment,’ and ‘Depression/anxiety.’
Pre-existing conditions were identified to be a strong risk factor for all symptoms except GI. Notably, age and disease severity were not linked with any symptoms. Increased levels of sCD58, an immunosuppressive factor, were linked with a lowering of all long COVID symptoms, particularly cardiorespiratory symptoms, and fatigue. Collectin-12 was associated with an increased risk of developing anxiety/depression, fatigue, and cardiorespiratory symptoms. COLEC12 initiates inflammation by triggering the alternative complement pathway and modifying leucocyte recruitment.
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