Concerns about the impact of pharmaceutical agents on fetal development have prompted researchers at Iowa State University to undertake a key study using a placenta-on-a-chip model. The study, focused on the transport of naltrexone (NTX) and its primary metabolite 6β-naltrexol, sheds light on their potential effects on the developing neural system of fetuses and their premature brains.
The placenta-on-a-chip model was fabricated and meticulously tested to simulate the transport of NTX/6β-naltrexol from the maternal channel to the fetal channel. From the fetal channel, the transported NTX/6β-naltrexol was collected and directed toward cultured N27 neural cells. The neural cells were then evaluated forThe study revealed intriguing findings, notably the significantly higher fold changes in interleukin-6 and tumor necrosis factor-alpha expression inexposed to NTX/6β-naltrexol.
These results hold particular significance since previous reports have linked elevated IL-6 and IL-1β expression levels to increased plasma levels in fetal brains and acute inflammatory insults in developing brains. Similarly, the possibility of TNF-α reducing embryonic
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