A study published in Crit_Care demonstrates the potential of the ClotPro device to identify and correct fibrinolysis resistance in critically ill patients.
: Table S1, Column A); however, the reductions measured were not as substantial as those achieved with 147 μg/mL plasminogen, median 12 [7.5–32.5]%.
The addition of plasminogen to ClotPro assays that do not contain exogenous t-PA was tested in 5 patients and resulted in changes of 1000 s. Plasminogen supplementation in the absence of t-PA appeared ineffective at inducing significant clot lysis.
In the normal healthy state, the fibrinolytic system is tightly regulated, as demonstrated by the low variation observed in our healthy control population. Significant recent attention has focused on fibrinolysis resistance that occurs in a proportion of patients with severe COVID-19 disease.
The amplitude of the fibrin clot formed in the FIB-test closely correlates with plasma fibrinogen levels [
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