Popular Weight Loss Drug Wegovy Lowers Risk of Stroke and Heart Attack, Drugmaker Says

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Popular Weight Loss Drug Wegovy Lowers Risk of Stroke and Heart Attack, Drugmaker Says
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Weight Loss Drug Wegovy May Decrease Risk of Stroke and Heart Attack, Drugmaker Says

as an indicator of health, but in the case of these drugs, it’s a crucial part of the FDA guidelines) and being in the 95“This drug works by sending satiety signals to your brain and slowing down your GI tract, effectively making you feel fuller longer,” Alan says. “It does have many modes of action, in addition to these major modes of action.”Again, the study hasn’t been peer-reviewed or published yet.

For the study, patients were either given shots once a week of Wegovy or a placebo, along with the standard of care to prevent major cardiovascular events over a period of five years. The trial found that people who took Wegovy had a “statistically significant and superior reduction” in the risk of major adverse cardiovascular events compared to the placebo, Novo Nordisk says.That’s the big question, and experts say it’s tricky to figure out without seeing the full study.

“We know that [excess] weight itself is a risk factor for heart disease, but it’s one of many different risk factors,” says, an interventional cardiologist and medical director of the Structural Heart Program at MemorialCare Saddleback Medical Center in Laguna Hills, CA. Alan agrees, noting that “the weight loss it produces is likely a large part of reducing risk.”

But Dr. Chen says that it’s “a little surprising” that weight loss itself would improve cardiovascular risk factors by as much as 20%. Worth noting: Novo Nordisk didn’t share how much weight the study participants lost. Experts say there’s likely more to this than just weight loss, though. “There must be some other effect on blood sugar control that hasn’t been studied yet,” Dr. Chen says.Novo Nordisk says in its press release that the drug was “safe and well-tolerated” in the latest study. However, Wegovy and similar semaglutide medications have been linked with gastroparesis, i.e. stomach paralysis, per.

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