A portable and affordable all-optical system for testing lab-on-a-chip human hearts SPIEtweets
and has entered commercial use for drug testing. Other commercial imaging systems for high-throughput analysis, e.g., fluorometric imaging plate reader by molecular devices, tend to use calcium imaging as a proxy for voltage mapping of drug responses due to the superior SNR by calcium-sensitive indicators compared to voltage-sensitive dyes.
The goal of this study was to build a stand-alone, compact, and inexpensive macroscopic system for all-optical electrophysiology, with capabilities for multiparametric mapping of voltage, calcium, and contraction waves in thin experimental preparations, such as layers of human iPSC-CMs. Toward this goal, we demonstrate the utility of a recent generation of machine-vision CMOS cameras, at a price that is two orders of magnitude lower than the cameras typically used in optical mapping.
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