Postdoctoral Fellowship: Ocular Genetics, Genomics, & Therapeutics
The Mootha Lab studies the molecular genetic basis of a common age-related eye disease called Fuchs’ endothelial corneal dystrophy. Fuchs’ dystrophy is the most common DNA trinucleotide repeat expansion disorder in humans and the leading indication for corneal transplantation in the United States. Dr. Mootha has elucidated that CUG repeat RNA is the “root cause” of Fuchs’ Dystrophy in a majority of cases. He has collaborated with David Corey, Ph.D.
The candidate will also participate in pre-clinical development of oligonucleotide therapeutics for eye disease. The candidate will have access to patient derived cell-, patient derived tissue-, and mouse- model systems to study repeat RNA mediated corneal and neurodegenerative disease. This is an exciting opportunity for a candidate to gain expertise in human genetics, genomics molecular genetics, transcriptomic methods, imaging of the mouse eye, and pre-clinical development of oligonucleotide and gene therapies.
The ideal candidate will hold a Ph.D. and/or M.D. degree and have strong cell and molecular biology skills. Information on our postdoctoral training program and benefits can be found in our
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