The success and challenges of developing different tuberculosis (TB) vaccine types.
By Dr. Priyom Bose, Ph.D.Oct 17 2023Reviewed by Lily Ramsey, LLM A recent Npj Vaccines study discussed the success and challenges of developing different tuberculosis vaccine types.
Bacille Calmette-Guérin is the most common and only licensed TB vaccine. This vaccine is safe for all age groups and communities except for immunocompromised people or those who have contracted human immunodeficiency virus . Effectiveness of different types of TB vaccines Twenty-one vaccine candidates are at various stages of clinical and preclinical development.
A newly developed VPM1002 vaccine, based on modified BCG, has demonstrated significant efficacy in Phase 3 clinical trials. The new vaccine contains a gene encoding listeriolysin O from Listeria monocytogenes and the removal of the BCG urease C gene. Subunit TB vaccines typically target specific proteins from M. tuberculosis and induce immune response. TB subunit vaccines, namely, H56:IC31, H4:IC31, and M72/AS01, have completed phase 2 clinical trials and demonstrated effective immunogenicity and safety in human volunteers.
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