Protein expression signature distinguishes early from late stage diffuse alveolar damage medrxivpreprint UniOfYork SARSCoV2 COVID19 DAD DiffuseAlveolarDamage
By Tarun Sai LomteDec 15 2022Reviewed by Aimee Molineux In a recent study posted to medRxiv* preprint server, researchers identified a protein expression signature that can distinguish early diffuse alveolar damage from late DAD in coronavirus disease 2019 patients.
Subjects were selected based on the histological evidence of DAD without additional complications related to pneumonia or cardiac failure. For spatial profiling, 4 μm-thick formalin-fixed paraffin-embedded sections were used. Slides were stained with cluster of differentiation 68 and CD3 as morphological markers and with a panel of 68 oligonucleotide-conjugated antibodies.
Next, the authors applied partial least-squares regression to identify those responsible for group segregation. Eight proteins were identified that largely reproduced what was noted with PCA and were used for classifying ROIs in a PLS linear discriminate analysis with leave-one-patient-out cross-validation. This yielded 93% predictive accuracy for EDAD and 80% for ODAD.
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