Parkinson's disease (PD), the second most common neurodegenerative disorder globally, has long baffled scientists with its progressive nature and debilitating effects on motor function.
Fujita Health UniversitySep 26 2024 Parkinson's disease , the second most common neurodegenerative disorder globally, has long baffled scientists with its progressive nature and debilitating effects on motor function.
"Our findings suggest that decreased uric acid levels in patients with PD are influenced by factors beyond purine metabolism, including external factors such as sex, weight, and age," said Dr. Watanabe, the lead author of the study. "This means the relationship between uric acid and PD is more nuanced than we previously thought, and it's about more than just oxidative stress.
This discovery is crucial, as it points to an impairment in the ATP recycling system. ATP is essential for cellular energy use, and its breakdown and recycling are vital for maintaining healthy cell function. In PD, this system seems to be malfunctioning, leading to an energy deficit that could further exacerbate the disease's symptoms.
Adenosine Triphosphate Antioxidant Blood Brain Compound Medicine Metabolism Metabolite Molecule Neurodegenerative Disorder Oxidative Stress Parkinson's Disease Purine Research Stress Students Uric Acid
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