A study published in BMCMedicine finds that insufficient rates of weight gain during the second trimester and excessive rates of weight gain during the third trimester are associated with a higher risk of neurodevelopmental disorders in the offspring.
Diagnostic codes. The codes for identifying exposures, outcomes, and covariates.Study cohort description by RGWG category. The characteristics of the study sample according to different categories of RGWG.Total GWG category and offspring risk of NDCs in full cohort. The association between the 3-category total GWG and offspring risks of autism, ADHD and ID, and the mutuality exclusive diagnoses of these three NDCs.RGWG category and offspring NDCs in full cohort.
STROBE checklist. The STROBE checklist showing our study was reported according to the STROBE checklist for cohort studies.This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
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lifex-fiber: an open tool for myofibers generation in cardiac computational models - BMC BioinformaticsBackground Modeling the whole cardiac function involves the solution of several complex multi-physics and multi-scale models that are highly computationally demanding, which call for simpler yet accurate, high-performance computational tools. Despite the efforts made by several research groups, no software for whole-heart fully-coupled cardiac simulations in the scientific community has reached full maturity yet. Results In this work we present $$\texttt {life}^{\texttt {x}}$$ life x -fiber, an innovative tool for the generation of myocardial fibers based on Laplace-Dirichlet Rule-Based Methods, which are the essential building blocks for modeling the electrophysiological, mechanical and electromechanical cardiac function, from single-chamber to whole-heart simulations. $$\texttt {life}^{\texttt {x}}$$ life x -fiber is the first publicly released module for cardiac simulations based on $$\texttt {life}^{\texttt {x}}$$ life x , an open-source, high-performance Finite Element solver for multi-physics, multi-scale and multi-domain problems developed in the framework of the iHEART project, which aims at making in silico experiments easily reproducible and accessible to a wide community of users, including those with a background in medicine or bio-engineering. Conclusions The tool presented in this document is intended to provide the scientific community with a computational tool that incorporates general state of the art models and solvers for simulating the cardiac function within a high-performance framework that exposes a user- and developer-friendly interface. This report comes with an extensive technical and mathematical documentation to welcome new users to the core structure of $$\texttt {life}^{\texttt {x}}$$ life x -fiber and to provide them with a possible approach to include the generated cardiac fibers into more sophisticated computational pipelines. In the near future, more modules will be successively published either as pre-compiled binaries for x86-64 L
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The coolest bikes from the Cycle Show 2023: Cannondale, Bianchi, Wilier, BMC, Enigma, Reilly, Cinelli & moreCheck out the coolest bikes from the weekend's CycleShow 2023: RideCannondale BianchiOfficial WilierTriestina Ride_BMC Enigmabikes Reillycycles & more cycling
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Visual narratives emphasizing communal benefits boost COVID-19 vaccination ratesIn a recent study published in the journal PNAS Nexus, researchers performed a three-wave online panel survey across 50 states in the United States of America (USA) and Washington D.C. in 2021 to test the influence of visual narrative-based policy communication messages on people's attitudes and behavior towards coronavirus disease 2019 (COVID-19) and benefits of COVID-19 vaccination.
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Welcome rise in cancer survival rates in Shropshire revealedThe rate of survival for cancer patients in the county one year on from their diagnosis is still rising, new figures show.
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Adverse birth outcomes and early-life infections after in utero exposure to corticosteroids for inflammatory bowel disease: a Danish nationwide cohort study - BMC MedicineBackground Systemic corticosteroids are often used to treat inflammatory bowel disease (IBD) flares during pregnancy as maintenance of disease remission is crucial to optimize pregnancy outcomes. However, there is little data regarding the effect of in utero exposure to corticosteroids on the risk of adverse birth outcomes and early-life infections in the offspring. Methods We used the Danish national registries to establish a nationwide cohort of all singleton live births in women with IBD from 1995 to 2015. Outcomes in children exposed in utero to corticosteroids were compared to those who were not exposed. In logistic and Cox proportional hazard regression models, we adjusted the outcomes (major congenital malformation, preterm birth, small for gestational age, low 5-min Apgar score, and infections) for confounders such as body mass index, smoking, comorbidity, and additional medical IBD treatment. Results After in utero exposure to corticosteroids at any time between 30 days prior to conception through the first trimester (n = 707), the adjusted hazard ratio of major congenital malformation was 1.28 (95% CI: 0.82–2.00) compared to children born to women with IBD, but not exposed to corticosteroids in utero (n = 9371). After in utero exposure to corticosteroids at any time during pregnancy (n = 1336), the adjusted odds ratios for preterm birth, small for gestational age, and low 5-min Apgar score were 2.45 (95% CI: 1.91–3.13), 1.21 (95% CI: 0.76–1.90), and 0.91 (95% CI: 0.33–2.52), respectively. Finally, the adjusted hazard ratio of overall infections in the first year of life was 1.14 (95% CI: 0.94–1.39). Conclusions This nationwide cohort study suggests that children of women with IBD exposed to corticosteroids in utero had an almost 2.5-fold increased risk of preterm birth. Use of corticosteroids is closely related to disease activity and we cannot adjust for the independent role of disease activity. It is however reassuring that the other examined birth and e
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Heads or tails first? Evolution of fetal orientation in ichthyosaurs, with a scrutiny of the prevailing hypothesis - BMC Ecology and EvolutionAccording to a longstanding paradigm, aquatic amniotes, including the Mesozoic marine reptile group Ichthyopterygia, give birth tail-first because head-first birth leads to increased asphyxiation risk of the fetus in the aquatic environment. Here, we draw upon published and original evidence to test two hypotheses: (1) Ichthyosaurs inherited viviparity from a terrestrial ancestor. (2) Asphyxiation risk is the main reason aquatic amniotes give birth tail-first. From the fossil evidence, we conclude that head-first birth is more prevalent in Ichthyopterygia than previously recognized and that a preference for tail-first birth likely arose in derived forms. This weakens the support for the terrestrial ancestry of viviparity in Ichthyopterygia. Our survey of extant viviparous amniotes indicates that fetal orientation at birth reflects a broad diversity of factors unrelated to aquatic vs. terrestrial habitat, further undermining the asphyxiation hypothesis. We propose that birth preference is based on parturitional mechanics or carrying efficiency rather than habitat.
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