A Review published in Cancer Cell International scrutinizes multiple diagnostic methods for glioblastoma, with a focus on proteomics methods and biosensors.
]. A single-cell surface sialoprotein in human GBM tissue, human astrocytes, fetal and adult human neural progenitor cells was characterized and accurately quantified using a bioorthogonal chemistry reporter strategy combined with label-free quantitative mass spectrometry were established for characterize and accurately quantify of GBM.
The subventricular zone is a key site of brain neurogenesis and is rich in neural stem cells. Because GBM tumors are often located near the SVZ, they can be classified as either SVZ− or SVZ+. Tumors that are in close proximity to the SVZ are categorized as SVZ+, while tumors that are distant from SVZ are classified as SVZ−.
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Bioinspired color-near infrared endoscopic imaging system for molecular guided cancer surgeryThe Journal of Biomedical Optics (JBO) is a Gold Open Access journal that publishes peer-reviewed papers on the use of novel optical systems and techniques for improved health care and biomedical research.
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False claims about cancer causing chemical in sunscreen - Full FactThe cancer-causing chemical benzene has contaminated cosmetic products in the past, often in very small amounts. But claims that most sunscreens contain it aren’t backed by the data—we find out why, and why this doesn’t mean sunscreen causes cancer.
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Woman's skin cancer diagnosis aged 17 despite never using a sunbedWoman's skin cancer diagnosis aged 17 despite never using a sunbed and always wearing cream
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Cancer survivor tackling London bike challenge with fatherJudith Kippax, 59, from Barnsley, is riding alongside her Royal Navy veteran father for charity.
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Exploring the role of pyroptosis in shaping the tumor microenvironment of colorectal cancer by bulk and single-cell RNA sequencing - Cancer Cell InternationalBackground Emerging studies have shown that pyroptosis plays a non-negligible role in the development and treatment of tumors. However, the mechanism of pyroptosis in colorectal cancer (CRC) remains still unclear. Therefore, this study investigated the role of pyroptosis in CRC. Methods A pyroptosis-related risk model was developed using univariate Cox regression and LASSO Cox regression analyses. Based on this model, pyroptosis-related risk scores (PRS) of CRC samples with OS time | 0 from Gene Expression Omnibus (GEO) database and The Cancer Genome Atlas (TCGA) database were calculated. The abundance of immune cells in CRC tumor microenvironment (TME) was predicted by single-sample gene-set enrichment analysis (ssGSEA). Then, the responses to chemotherapy and immunotherapy were predicted by pRRophetic algorithm, the tumor immune dysfunction and exclusion (TIDE) and SubMap algorithms, respectively. Moreover, the Cancer Therapeutics Response Portal (CTRP) and PRISM Repurposing dataset (PRISM) were used to explore novel drug treatment strategies of CRC. Finally, we investigated pyroptosis-related genes in the level of single-cell and validated the expression levels of these genes between normal and CRC cell lines by RT-qPCR. Results Survival analysis showed that CRC samples with low PRS had better overall survival (OS) and progression-free survival (PFS). CRC samples with low PRS had higher immune-related gene expression and immune cell infiltration than those with high PRS. Besides, CRC samples with low PRS were more likely to benefit from 5-fluorouracil based chemotherapy and anti-PD-1 immunotherapy. In novel drug prediction, some compounds such as C6-ceramide and noretynodrel, were inferred as potential drugs for CRC with different PRS. Single-cell analysis revealed pyroptosis-related genes were highly expressed in tumor cells. RT-qPCR also demonstrated different expression levels of these genes between normal and CRC cell lines. Conclusions Taken together, this s
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ITV News reporter Emily Morgan dies aged 45 after battle with lung cancerEmily, who was the channel's health and science editor, played a key role in covering the Covid pandemic.
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