Researchers from the University of California, Irvine have just published a study that projects 93 million U.S. adults that are overweight and obese may be suitable for the 2.4 mg dosage of semaglutide, a weight loss medication known under the brand name Wegovy.
, estimating a reduction in 10-year cardiovascular disease risk of 1.8% from 10.15% to 8.34% , projecting up to 1.5 million cardiovascular events could be potentially prevented in 10 years. The analysis did not estimate the additional cardiovascular events that might be prevented from treatment among the approximately 10 million estimated eligible persons with cardiovascular disease.
The projected 18% reduction in cardiovascular events in persons who are overweight or are obese but without cardiovascular disease compares favorably to the recently announced top line results of the SELECT trial, which studied Wegovy in persons with cardiovascular disease and showed an actual 20% reduction in future cardiovascular events."It is one of the biggest advances in the obesity and cardiovascular medicine world," said Wong.
"We now have a weight control therapy that also significantly reduces cardiovascular events beyond the diabetes population where it was originally studied," said Wong."It should be considered for patients who are obese or overweight with other risk factors where cardiovascular disease is their leading cause of disability and death.
Additionally, Wong noted that given the costs of these therapies, that better access is needed for our high risk underserved populations who may benefit from them. Wegovy is a glucagon-like peptide 1 receptor agonist injectable therapy approved by the Federal Drug Administration for chronic weight management in adults with who are obese or overweight with at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol. Wegovy is to be used in addition to a reduced calorie diet and increased physical activity.Nathan D.
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