How do we get to an effective and scalable cure for HIV? In this 2021 Review, ProfSharonLewin, Steven Deeks and colleagues from the iasociety Global Scientific Strategy working group outline key research priorities for the next 5 years WorldAIDSDay
The Global Cure Strategy was created using a full online process during the COVID-19 pandemic from November 2020 to August 2021. The co-chairs of the initiative identified the major topics which were divided into eight subthemes, each with its own working group, which included a chair, three scientific experts, at least one community member, an IAS Research-for-Cure fellow, and an industry representative.
The Global Cure Strategy was further refined through a broad, online stakeholder consultation, including an online survey, a review by key stakeholders in the field, and interviews with select experts and opinion leaders . The survey received 162 responses, primarily from people working in academia, nongovernmental organizations, and hospitals or research institutions; 11% of respondents were from organizations of people living with HIV, and 4% were from industry.
Develop imaging modalities that quantify the size, distribution, and activity of the reservoir in tissuesDevelop assays for point-of-care and eventually at-home viral-load monitoringDefine the role of HIV-specific antibodies, B cells, and the innate immune response in virus elimination or controlOptimize human organoid models, as well as mouse and nonhuman primate models, for cure- and remission-related studiesDevelop strategies to permanently silence the provirusDefine the role of viral...
Characterize the establishment, persistence, and potential for preventing or reversing HIV latency in infants and children on ARTTest HIV immunotherapies and other strategies in infants and childrenExpand community/stakeholder engagement and capacity buildingEstablish standards for the safe conduct of clinical researchBuild capacity for basic discovery research and clinical trials in high-burden, resource-limited settingsA shared definition of the HIV reservoir is crucial for researchers,...
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