Researchers have discovered a novel approach for engrafting engineered cells into injured lung tissue. These findings may lead to new ways for treating lung diseases, such as emphysema, pulmonary fibrosis and COVID-19. The two studies describe the methodologies for engineering lung stem cells and transplanting them into injured experimental lungs without immunosuppression.
Researchers from the Center for Regenerative Medicine , a joint venture between Boston University and Boston Medical Center, have discovered a novel approach for engrafting engineered cells into injured lung tissue. These findings may lead to new ways for treating lung diseases, such as emphysema, pulmonary fibrosis and COVID-19.
"By differentiating experimental model and human pluripotent stem cells into airway basal cells in the laboratory dish, we were then able to use these cells to reconstitute the stem cell compartment of the injured model airways in vivo . This resulted in life-long engraftment of the engineered basal cells in an immunocompetent model.
The researchers believe the reconstitution of lung stem and progenitor cells in the airways and alveoli using cells engineered from pluripotent stem cells is an important finding with many implications for the future treatment of lung diseases that involve injury, degeneration or mutations.
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