The Houston Methodist team employed a bacterial protein which effectively reduced cholesterol levels by more than 40% within a span of three hours. Researchers at Houston Methodist have restored fertility in infertile mice by lowering their high cholesterol levels using a bacterial protein, reinf
Houston Methodist scientists successfully reversed infertility in sterile mice by reducing high cholesterol levels using a bacterial protein called serum opacity factor. This discovery strengthens the link between high cholesterol and female infertility, offering potential future treatment options for women struggling to conceive.
The findings were recently published in the American Society for Biochemistry and Molecular Biology’sSerum opacity factor sets off a biochemical cascade that ultimately results in getting rid of excess cholesterol. ApoE proteins on lipid-rich HDL bind to their receptors in the liver initiating cholesterol’s breakdown. High-density lipoprotein ; Apolipoprotein E ; Apolipoprotein AI .
“Both HDLs and LDLs contain a mixture of free and esterified cholesterol, and free cholesterol is known to be toxic to many tissues,” said Henry J. Pownall, Ph.D., professor of biochemistry in medicine at the Houston Methodist Research Institute and corresponding author on the study. “So, any dysfunction in HDL could be a risk factor for several diseases, too.”
As predicted, when the researchers fed the sterile mice with a lipid-lowering drug, both LDL and HDL cholesterol levels reduced, and the animals were temporarily rescued from infertility. Motivated by these results, they turned to the bacterial protein serum opacity factor, known to be highly selective for HDL.
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