A small number of HIV-infected cells remain in the tissues of people living with the virus and who are undergoing antiretroviral therapy. These viral reservoirs, real obstacles to the cure of HIV, have long been known to exist.
is interrupted, are concentrated in the deep tissues of the spleen and lymph nodes, organs of the immune system.
"We owe these results first and foremost to the generosity of two Canadian men who were at the end of their lives, suffering from HIV and on antiretroviral therapy," said Chomont. "By donating their bodies to science, these men made a unique contribution to our work. It is extremely rare to have access to post-mortem analysis for the presence or absence of viral reservoirs in so many organs of the sameNicolas Chomont, professor at Université de Montréal and researcher at the CHUM Research Centre and Caroline Dufour, doctoral student at UdeM.
Using a protocol for analyzing the few viral genomes persisting in tissues, she was able to identify the organs in which"live" HIV preferentially hides.and spleen," said Chomont."In the tissues of the Edmonton participant, they were found predominantly in the same organs, although lower concentrations could also be detected in other tissues.
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