Fecal microbe transplants from healthy donors can treat patients with recurrent Clostridium difficile infections. However, after tens of thousands transplants, little was known about which donor strains provide long-term engraftment, and which engraft early after the transplant.
Reviewed by Danielle Ellis, B.Sc.Oct 13 2023 Most failures of fecal microbe transplantation occur in the first four weeks.
Now microbiome experts at the University of Alabama at Birmingham have taken that 2021 study, and a similar study for children who had C. difficile infections, a step further. UAB researchers Hyunmin Koo, Ph.D., and Casey D. Morrow, Ph.D., focused on the commensal microbe Bacteroides vulgatus, one of the most common species found in healthy guts.
"Based on their known functions, the identification of both the chitobiase -; and subsequently a complete commensal colonization factor complex -; and fimbrillin proteins supports the involvement of these proteins in B. vulgatus colonization," Morrow said.
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Improving fecal microbe transplants: Study identifies B. vulgatus genes that correlate with early colonizationFecal microbe transplants from healthy donors can treat patients with recurrent Clostridium difficile infections. However, after tens of thousands transplants, little was known about which donor strains provide long-term engraftment, and which engraft early after the transplant.
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