An international team of researchers led by Lancaster University have made a promising breakthrough in the development of drugs to treat Alzheimer's Disease.
Lancaster UniversityOct 3 2024 An international team of researchers led by Lancaster University have made a promising breakthrough in the development of drugs to treat Alzheimer's Disease.
The Lancaster University team included the late Professor David Allsop and the late Dr Nigel Fullwood who were both from the Faculty of Biomedical and Life Sciences at Lancaster University. A significant breakthrough Tau proteins play a crucial role in maintaining the structure and function of neurons . But in Alzheimer's disease, these proteins malfunction, clumping together to form long, twisting fibrils.
Amritpal Mudher, Professor of Neuroscience at the University of Southampton, said: "There are two regions of the Tau protein that act like a zipper to enable it to aggregate. For the first time, we have a drug which is effective in inhibiting both these regions. This dual-targeting mechanism is significant because it addresses both domains that stimulate Tau aggregation, potentially paving the way for more effective treatments for neurodegenerative diseases like Alzheimer's.
The researchers found the drug suppressed neurodegeneration and extended the lives of the flies by around two weeks – a significant extension considering the life span of the insects.
Brain Cell Dementia Drugs Fruit Laboratory Neurodegeneration Neurodegenerative Diseases Neurons Protein Research Tau Protein
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