Researchers report the development of robust candidate single immunization PNP hydrogel COVID vaccines biorxivpreprint Stanford StanfordMed univbordeaux_EN UW COVID19 coronavirus covid vaccine vaccination
By Pooja Toshniwal PahariaDec 16 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the bioRxiv* preprint server, researchers developed a one-dose subunit vaccine for the induction of durable, potent, and broad immunity against severe acute respiratory syndrome coronavirus 2 .
About the study In the present study, researchers developed single-dose PNP hydrogel subunit vaccines for immune protection against coronavirus disease 2019 . The best-performing one-dose SARS-CoV-2 RBD NP PNP hydrogel vaccine was compared with regular prime-boost soluble RBD NP vaccines in saline, which were administered three weeks apart, following which, the murine serum samples were obtained over 10 weeks. The anti-RBD immunoglobulin G titers were measured by enzyme-linked immunosorbent assays .
Results Compared to the soluble prime-boost regimen vaccines, the one-dose PNP hydrogel vaccines induced greater, more durable, potent, and broader humoral responses, with consistent and greater SARS-CoV-2 neutralization. The hydrogel vaccines were self-healing and shear-thinning and, therefore, could be administered as simple injections and formed robust subcutaneous depots after injection.
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