By recruiting the immune system to combat tumor cells, immunotherapy has improved survival rates, offering hope to millions of cancer patients. However, only about one in five people responds favorably to these treatments.
Washington University School of Medicine Aug 7 2024
Robert D. Schreiber, PhD, Study Senior Author, Andrew M. and Jane M. Bursky Distinguished Professor, Department of Pathology & Immunology, and Director, Bursky Center for Human Immunology & Immunotherapy, Washington University School of MedicineCancer vaccines represent a new approach to personalize cancer immunotherapy. Aimed at the mutant proteins specific to a patient's tumor, such vaccines induce killer T cells to attack tumor cells while leaving healthy cells unharmed.
Related Stories"We thought that more helper T cell activation would optimize elimination of the sarcoma tumors in mice," Sultan said. "Instead, we found that vaccines containing high doses of helper T cell targets induced inhibitory Tr1 cells that completely blocked tumor elimination. We know that Tr1 cells normally control an overactive immune system, but this is the first time they have been shown to dampen its fight against cancer.
Biotherapeutics Cancer Cancer Immunotherapy Cell Immune System Immunology Medicine Pathology Research Sarcoma Tumor Vaccine
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