A new set of protocols will allow researchers to expand the way they look at pathogens.
The principle of physically expanding biological study samples for imaging is known as expansion microscopy. The technique uses a hydrogel to homogenously expandand decrowd biomolecules, providing researchers with a way to visualize fine details using standardized microscopes instead of expensive, specialized tools.
MicroMagnify, the latest protocol published by the Zhao Lab, takes their work a step forward. The protocol expands complex microbial cells and infected tissues without distortion, allowing for enhanced high-plex fluorescence imaging.
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