Study proposes role for gamma oscillations in future treatment. Researchers have found that restoring gamma signals in the olfactory bulb, a brain region processing smells, can counteract depression. This breakthrough discovery highlights the potential of gamma-enhancement as a new approach to trea
In a new study, scientists discovered that restoring certain gamma signals in a brain region responsible for processing smells can help alleviate depression. This discovery suggests potential new methods for treating depression, particularly in instances where conventional medications are ineffective.Researchers have found that restoring gamma signals in the olfactory bulb, a brain region processing smells, can counteract depression.
To test this theory, the current study authors shut down the function of the bulb using genetic and cell signaling techniques, observed a related increase of depression-like behaviors in study rodents, and then reversed these behaviors using a device that boosted gamma signals of the brain at their natural pace.
Removal of the bulb represents an older animal model for the study of major depression, but the process causes structural damage that may cloud researchers’ view of disease mechanisms. Thus, the current research team designed a reversible method to avert damage, starting with a single, engineered strand of, which when injected into neurons in the olfactory bulbs of rodents caused the cells to build certain protein receptors on their surfaces.
Specifically, the tests looked at how long animals would spend in an open space , whether they stopped swimming earlier when submerged , whether they stopped drinking sugar water , and whether they refused to enter a maze .
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