Diogo Dalot and Marcus Rashford came off before the hour in Man United's 3-0 victory over Leicester City.
Ruud van Nistelrooy said his double substitution early in the second half was "necessary" as Manchester United beat Leicester City 3-0.
Evans slotted in at centre back and Noussair Mazraoui switched from left back to right back as Lisandro Martinez shifted to left back. Garnacho was a straight swap for Rashford on the left wing. Garnacho curled in his seventh goal of the season and his second during Van Nistelrooy's four-game interim spell. The 20-year-old is United's top scorer this term and had started their previous seven matches, having started 38 successive games last season.
"And there are other players in the squad who are back. Jonny Evans, fantastic, comes in and does the job. And Lisandro going to left back and doing their jobs.
Diogo Dalot Marcus Rashford Manchester United FC
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