Scientists Develop a Cancer Vaccine to Simultaneously Kill and Prevent Brain Cancer harvardmed BrighamWomens ScienceMagazine cancer cancervaccine braincancer vaccine vaccination
Jan 30 2023Reviewed by Danielle Ellis, B.Sc. Scientists are harnessing a new way to turn cancer cells into potent, anti-cancer agents. In the latest work from the lab of Khalid Shah, MS, PhD, at Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, investigators have developed a new cell therapy approach to eliminate established tumors and induce long-term immunity, training the immune system so that it can prevent cancer from recurring.
The team tested their repurposed CRISPR-enhanced and reverse-engineered therapeutic tumor cells in different mice strains, including the one that bore bone marrow, liver, and thymus cells derived from humans, mimicking the human immune microenvironment. Shah’s team also built a two-layered safety switch into the cancer cell, which, when activated, eradicates ThTCs if needed. This dual-action cell therapy was safe, applicable, and efficacious in these models, suggesting a roadmap toward therapy.
In this study, we developed a bifunctional therapeutic strategy by transforming living tumor cells into a potent agent that concomitantly drives direct tumor killing and antitumor immunity.
To eliminate the possibility of unwanted secondary tumor initiation, we implemented a dual safety switch comprising of rapamycin-activated caspase 9 and herpes simplex virus-1 thymidine kinase in our therapeutic tumor cells." - Khalid Shah, Vice Chairman Neurosurgery, Professor Harvard Medical School Founder and Director CSTI.
Deutschland Neuesten Nachrichten, Deutschland Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
'Do not take a leaf out of my book'A Yorkshire mum is urging other women to attend their smear tests after battling cervical cancer.
Weiterlesen »
Dumbarton mum in agony after waiting almost a year for cervical cancer testA Freedom Of Information (FOI) request discovered the average wait for a colposcopy in NHS Greater Glasgow and Clyde is 19-and-a-half weeks - the target time is six weeks.
Weiterlesen »
Urgent search for missing radioactive capsule that causes burns and could lead to cancerExperts are desperately trying to track down a dangerous radioactive capsule lost somewhere on an 870 mile stretch of road in Western Australia.
Weiterlesen »
Tributes to Yoda the owl after he dies following cancer find at Scots sanctuaryThe 13-year-old, who is named after the Star Wars character and has lived at the Scottish Owl Centre for the last 11 years, passed away at the sanctuary
Weiterlesen »
'Warrior' teen who beat cancer aged six needs £100k after 'terrible news'Brave Jahzara Edmondson said: 'It's okay mum - I will go through it again and beat it again'
Weiterlesen »